Trepanation is the procedure of drilling a hole in the skull. It is said to increase the blood circulation and improve pressure inside the skull. It is also said to bring out a person's sixth sense, the ability to use ESP, see ghosts, move objects with one's mind. This is speculative fiction based on the concept of trepanation.
[From Anime News Network]:In Shinjuku Kabuki-Cho, the biggest sin town in Japan, there are two crazy guys. Ichi is a coward and a wimp, but once he breaks into tears, he turns into a human weapon. With great martial arts skill and a blade hidden in his boots, he butchers a bunch of enemies into mincemeat in the blink of an eye. His arch enemy is Kakihara, a yakuza boss who's tired of everything, including himself. Only when he pierces, cuts, and burns his own and other people's bodies does he feel that he is alive.Warning: Very graphic content.